Comparing the outcomes of statins and PCSK9 inhibitors in LDL management in patients with heterozygous familial hypercholesterolemia (HeFH) and diabetes

Asif Shah; Mahnoor Bashir; Rawish Gul; Alina murad; Brikhna Khattak

doi:10.62497/IRABCS.2024.39

Authors

Asif shah Saidu Teaching Hospitals, Swat, Pakistan Author
Mahnoor Bashir Women Medical College, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan Author
Rawish Gul Saidu Teaching Hospitals, Swat, Pakistan Author
Alina murad Women Medical College, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan Author
Brikhna Khttak Women Medical College, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan Author

DOI:

https://doi.org/10.62497/IRABCS.2024.39

Keywords:

heterozygous familial hypercholesterolemia, diabetes mellitus, statins, PCSK9 inhibitors, LDL-C reduction, cardiovascular outcome, patient satisfaction

Abstract

Background: Aggressive lipid-lowering methods are required for cardiovascular risk management when heterozygous familial hypercholesterolemia (HeFH) is combined with diabetes mellitus. Though statins have been the mainstay of treatment, a viable substitute is the development of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors. Comparative information about their safety and effectiveness in this population is still lacking, though.

Aim: This study aims to systematically compare the outcomes of statins and PCSK9 inhibitors in LDL management for patients with HeFH and diabetes.

Methodology: A retrospective cohort study was conducted at Hayabad Medical Complex, encompassing 62 individuals with HeFH and diabetes mellitus. Data on demographic characteristics, treatment regimens, LDL-C reduction efficacy, cardiovascular outcomes, safety profile, and patient adherence were analyzed.

Results: PCSK9 inhibitors demonstrated superior efficacy in reducing LDL-C levels compared to statins, achieving a mean reduction of 70.9% versus 55.8%, respectively. Moreover, individuals receiving PCSK9 inhibitors experienced a significantly lower incidence of cardiovascular events (2 events vs. 6 events) and reported higher levels of patient satisfaction. Both therapies exhibited a favorable safety profile.

Conclusion: Our findings underscore the potential of PCSK9 inhibitors as a preferred therapeutic option over statins in patients with HeFH and diabetes, offering superior LDL-C reduction efficacy, cardiovascular risk reduction, and patient satisfaction. These results highlight the importance of personalized treatment approaches in optimizing cardiovascular risk management.

Keywords: heterozygous Familial Hypercholesterolemia, diabetes mellitus, statins, PCSK9 inhibitors, LDL-C reduction, cardiovascular outcomes, patient satisfaction

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Author Biographies

Asif shah, Saidu Teaching Hospitals, Swat, Pakistan

MBBS
Mahnoor Bashir, Women Medical College, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan

MBBS
Rawish Gul, Saidu Teaching Hospitals, Swat, Pakistan

MBBS
Alina murad, Women Medical College, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan

MBBS
Brikhna Khttak, Women Medical College, Benazir Bhutto Shaheed Teaching Hospital, Abbottabad, Pakistan

MBBS

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