Targeting protein-protein interactions for therapeutic intervention in Parkinson's disease to delay progression.

Authors

  • Hassaan Ahmad Rehman medical college Author
  • Syeda Farwa Zaidi Rehman medical college Author
  • Abdullah Jan Safi Pak international medical college Author
  • Sadaqat Ullah Rehmat Ayub Medical College, Abbottabad. Author
  • Safi Ullah Khyber medical college Peshawar Author
  • Summet Kumar SMBBMC Author

DOI:

https://doi.org/10.62497/IRABCS.2024.37

Abstract

Background: Parkinson's disease (PD) is a neurodegenerative condition with few treatments to slow or stop development. Protein-protein interactions (PPIs) are intriguing therapeutic targets. This research examined the safety and effectiveness of a new Parkinson's disease medication targeting PPIs.

Methods: After enrollment, 60 individuals were randomly assigned to the treatment and control groups. MDS-UPDRS Part III score change from baseline to week 12 was the main outcome measure. Secondary outcome measures were the Hoehn and Yahr scale, NMSS, and Montreal Cognitive Assessment. Study-wide adverse events were tracked.

Results: Compared to the control group, the treatment group exhibited a substantial improvement in MDS-UPDRS Part III score (p < 0.001). Additionally, the therapy group showed substantial improvements in Hoehn and Yahr stage, NMSS score, and MoCA score compared to the control group (p < 0.001). No significant adverse effects were documented with the experimental medication.

Conclusion: This research suggests that targeting PPIs may treat Parkinson's disease. No harmful side effects were detected with the experimental medication, which improved motor and non-motor symptoms in PD patients. These results require more study to determine the long-term safety and effectiveness of targeting PPIs in Parkinson's disease.

 

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Published

07/02/2024

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How to Cite

1.
Ahmad HA, Zaidi SF, Jan Safi AJS, Sadaqat Ullah Rehmat, Safi Ullah, Summet Kumar. Targeting protein-protein interactions for therapeutic intervention in Parkinson’s disease to delay progression. IRABCS [Internet]. 2024 Jul. 2 [cited 2024 Jul. 20];2(1):62-7. Available from: https://irabcs.com/ojs/article/view/37

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