Impact of Hyperuricemia on Coronary Artery Disease Severity in Patients with Diabetes
Keywords:
hyperuricemia, serum uric acid, coronary artery disease, diabetes, SYNTAX score, cardiovascular risk factorsAbstract
Introduction: Hyperuricemia's association with cardiovascular diseases, including coronary artery disease (CAD), remains uncertain, particularly as an independent risk factor. The study aims to investigate the relationship between hyperuricemia and CAD severity in patients with diabetes.
Methods: A descriptive study design was employed, enrolling 303 patients diagnosed with CAD, aged 17 years and above. Serum uric acid levels were measured, and CAD severity was assessed using the SYNTAX score. Statistical analyses, including unpaired t-tests and multivariate linear regression, were performed to evaluate the association between hyperuricemia and CAD severity.
Results: The study participants had a mean age of 59.26 years and were predominantly male (66.9%). The majority of participants did not have diabetes (51.4%), while 37.1% had been diagnosed with diabetes and 11.4% had an unknown diabetic status. The study revealed a positive and independent association between hyperuricemia and the severity of CAD in patients with diabetes. Hypertension was prevalent in 52.6% of participants. The mean hba1c value was 6.7617 mmol/l, with a maximum frequency observed for the hba1c value of 5.3 mmol/l. Elevated serum uric acid levels were identified as a significant risk factor for CAD severity, irrespective of other traditional cardiovascular risk factors.
Conclusion: The study found a high prevalence of hypertension and diabetes among the participants. The mean hba1c level was also elevated, suggesting that glycemic control was not optimal in many participants. These findings suggest that there is a need for effective interventions to improve cardiovascular health among patients with diabetes.
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