Association between high-density lipoprotein (HDL) levels and severity of coronary artery disease on angiography


  • Muhammad Muttahir Medicine and Surgery, Khyber Medical College, Peshawar, Pakistan Author
  • Sasha BScN RN Vereecken Department of Clinical Science, Saint James School of Medicine, Anguilla Author
  • Bibi Zahida Kazmi MBBS, Khyber Medical University Institute of Medical Sciences, Kohat, Pakistan Author
  • Muhammad Afnan MBBS, Khyber Medical University Institute of Medical Sciences, Kohat, Pakistan Author


high-density lipoprotein, coronary artery  disease, angiography, hypertension, diabetes, risk  stratification


Background: This retrospective observational study's goal was to evaluate if high-density lipoprotein (HDL) levels correlate with the degree of coronary artery disease (CAD), as assessed by angiography.

Methodology: The research comprised 160 individuals who had coronary angiography. Data on the 
demographics of the patients, as well as their medical information, HDL levels, and angiographic findings were collected using a standardized proforma. The severity of CAD was assessed using the SYNTAX score. Statistical analysis, including independent “t-tests, chi-square tests, and correlation analysis, was performed using SPSS”.

Results: The results revealed a significant association between HDL levels and CAD severity. When 
the comparison was done to patients with mild-to-moderate CAD, the ones with severe CAD had considerably lower mean HDL values (p≤0.001). Even after accounting for any confounding variables, there was still a substantial correlation between HDL levels and the severity of CAD. Furthermore, significant associations were found between HDL levels and gender, hypertension, and diabetes, indicating a potential interplay between these factors and HDL in CAD development.

Conclusion: This study provides evidence for the association between lower HDL levels and increased CAD severity. Maintaining optimal HDL levels may have clinical implications for risk stratification and management of CAD. Gender-specific differences and associations with comorbidities such as hypertension and diabetes highlight the need for tailored approaches in CAD prevention and treatment. Prospective research with bigger and more varied populations is necessary to confirm these results and investigate the underlying causes.


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07/01/2023 — Updated on 07/01/2023




Research Articles


How to Cite

Muttahir M, Vereecken SBR, Kazmi BZ, Afnan M. Association between high-density lipoprotein (HDL) levels and severity of coronary artery disease on angiography. IRABCS [Internet]. 2023 Jul. 1 [cited 2024 Jun. 16];1(1):44-8. Available from:

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