Association between obesity and risk of kidney stones: exploring the rule of life style factors

Authors

  • Ayesh Anwar Peshawar Medical College, Peshawar Author
  • Hanif uz Zaman Nowshera Medical College, Nowshera Author
  • Syed Abdul Haseeb Peshawar Medical College, Peshawar Author
  • Hassaan Ahmad Rehman Medical College, Peshawar Author
  • Awalrehman Hayatabad Medical Complex, Peshawar Author
  • Imran Khan Pak International Medical College, Peshawar Author

DOI:

https://doi.org/10.62497/IRABCS.2024.43

Keywords:

Kidney stones, obesity, lifestyle factors, dietary habits, fluid intake, physical activity, medication use, prospective cohort study

Abstract

Introduction: Kidney stones are a prevalent health concern, with obesity recognized as a significant risk factor. Understanding the interplay between obesity and lifestyle factors in stone formation is crucial. This study investigates this association, focusing on dietary habits, fluid intake, physical activity, and medication use.

Methods: A one-year prospective April 2023–March 2024 saw the conduct of a cohort study at the Pakistan Academy of Medical Sciences (PIMS) in Pakistan's Islamabad. 88 participants were enrolled, with baseline data including demographics, BMI, medical history, and lifestyle factors. Follow-up assessments monitored weight changes, urinary parameters, and kidney stone incidence. Multivariate regression analysis explored associations between obesity, lifestyle factors, and stone risk.

Results: Obese participants exhibited higher comorbidity prevalence and medication use. Over the study, obese participants gained 3.7 kg, while non-obese lost 1.5 kg. Obese individuals had elevated urinary calcium and oxalate, and lower citrate levels. Kidney stone incidence was 16.7% in obese and 9.5% in non-obese participants. Multivariate analysis identified obesity, high animal protein intake, and low fluid consumption as significant predictors of stone risk among obese individuals.

Conclusion: This study underscores the complex relationship between obesity, lifestyle factors, and kidney stone risk. Modifiable factors like dietary habits and fluid intake play crucial roles in stone formation. Insights from this research can inform targeted interventions to reduce stone burden and improve health outcomes in obese individuals.

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References

Taylor EN, Stampfer MJ, Curhan GC. Obesity, weight gain, and the risk of kidney stones. Jama. 2005 Jan 26;293(4):455-62.

Siener R, Metzner C. Dietary weight loss strategies for kidney stone patients. World Journal of Urology. 2023 May;41(5):1221-8.

Lin W, Ye Q, Lin ME. Relationship between the weight-adjusted-waist index and kidney stone: a population-based study. Wo Paiste HJ, Moradi L, Assimos DG, Wood KD, Dangle PP. Is There an Association between Childhood Obesity and Pediatric Kidney Stone Disease? A Literature Review. Uro. 2021 Jul 24;1(3):108-17

Paiste HJ, Moradi L, Assimos DG, Wood KD, Dangle PP. Is There an Association between Childhood Obesity and Pediatric Kidney Stone Disease? A Literature Review. Uro. 2021 Jul 24;1(3):108-17.

Stamatelou K, Goldfarb DS. Epidemiology of kidney stones. InHealthcare 2023 Feb 2 (Vol. 11, No. 3, p. 424). MDPI.

Kim SY, Chung J, Park DS, Yoo DM, Bang WJ, Choi HG. The reciprocal relationship between osteoporosis and renal stones. Journal of Clinical Medicine. 2022 Nov 8;11(22):6614.

Khan SR. Is oxidative stress, a link between nephrolithiasis and obesity, hypertension, diabetes, chronic kidney disease, metabolic syndrome?. Urological research. 2012 Apr;40:95-112.

Moludi J, Fateh HL, Pasdar Y, Moradinazar M, Sheikhi L, Saber A, Kamari N, Bonyani M, Najafi F, Dey P. Association of dietary inflammatory index with chronic kidney disease and kidney stones in Iranian adults: A cross-sectional study within the Ravansar non-communicable diseases cohort. Frontiers in nutrition. 2022 Oct 12;9:955562.

Zyoud SE, Abushamma F, Salameh H, Abushanab AS, Koni A, Abu Taha A, Al-Jabi SW, Shahwan M, Jairoun AA, Shakhshir MH. Exploring the nutritional landscape and emerging trends in kidney stone research: visualization and bibliometric analysis. Translational Medicine Communications. 2024 Mar 12;9(1):8.

Morgan MS, Pearle MS. Medical management of renal stones. Bmj. 2016 Mar 14;352.

Roudakova K, Monga M. The evolving epidemiology of stone disease. Indian Journal of Urology. 2014 Jan 1;30(1):44-8.

Khan SR, Pearle MS, Robertson WG, Gambaro G, Canales BK, Doizi S, Traxer O, Tiselius HG. Kidney stones. Nature reviews Disease primers. 2016 Feb 25;2(1):1-23.

Sakhaee K, Poindexter J, Aguirre C. The effects of bariatric surgery on bone and nephrolithiasis. Bone. 2016 Mar 1;84:1-8.

Sakhaee K, Poindexter J, Aguirre C. The effects of bariatric surgery on bone and nephrolithiasis. Bone. 2016 Mar 1;84:1-8.

Ding Q, Ouyang J, Fan B, Cao C, Fan Z, Ding L, Li F, Tu W, Jin X, Wang J, Shi Y. Association between dyslipidemia and nephrolithiasis risk in a Chinese population. Urologia internationalis. 2019 Jan 23;103(2):156-65.

Chang CW, Ke HL, Lee JI, Lee YC, Jhan JH, Wang HS, Shen JT, Tsao YH, Huang SP, Geng JH. Metabolic syndrome increases the risk of kidney stone disease: a cross-sectional and longitudinal cohort study. Journal of personalized medicine. 2021 Nov 6;11(11):1154.

Khan J, Shaw S. Risk of multiple lower and upper urinary tract problems among male older adults with type-2 diabetes: a population-based study. The Aging Male. 2023 Dec 31;26(1):2208658.

Lundeen C, Lim JR, Scotland KB, Ardekani RS, Penniston KL, Streeper NM, Chi T, Landman J, Viprakasit DP, Chew BH. What is the relationship of stress to patients’ kidney stone-related quality of life?. Canadian Urological Association Journal. 2021 May;15(5):E256.

Baum M. Pediatric nephrolithiasis. Current opinion in pediatrics. 2020 Apr 1;32(2):261-4.

Bagga HS, Chi T, Miller J, Stoller ML. New insights into the pathogenesis of renal calculi. Urologic Clinics. 2013 Feb 1;40(1):1-2.

Abu-Ghanem Y, Kleinmann N, Winkler HZ, Zilberman DE. Nephrolithiasis in Israel: epidemiological characteristics of return patients in a tertiary care center. Isr Med Assoc J. 2016 Dec 1;18(12):725-8.

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Published

06/30/2024

How to Cite

1.
Anwar A, Hanif uz Zaman, Haseeb SA, Ahmad H, Awalrehman, Khan I. Association between obesity and risk of kidney stones: exploring the rule of life style factors. IRABCS [Internet]. 2024 Jun. 30 [cited 2024 Jul. 20];2(1):91-5. Available from: https://irabcs.com/ojs/article/view/43

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