Relationship between Vitamin D and Parathyroid Hormone levels along with Simvastatin effect on serum calcium levels in postmenopausal women with osteoarthritis

Vitamin D, Parathyroid Hormone, and Simvastatin in Postmenopausal Women with Osteoarthritis


  • Dr. Huma Fatima tu zara Khyber Medical College Peshawar Author
  • Dr. Majeed Ullah Resident Neurologist, Hayat abad Medical Complex Author
  • Dr. Aqsa Atta Human Nutrition and Dietetics, Nishtar Medical University Multan, Pakistan Author
  • Dr. Areeba Abdullah MBBS, Liaquat National Hospital and Medical Center, Jinnah Postgraduate Medical Center , Karachi Author


Osteoarthritis , Vitamin D, Postmenopausal women , Parathyroid hormone


Background: Osteoarthritis (OA) is a prevalent musculoskeletal condition that often affects postmenopausal women. This study aimed to investigate the relationship between metabolic factors, including serum vitamin D, parathyroid hormone (PTH), and calcium levels, and the severity of OA in postmenopausal women. Additionally, the potential impact of simvastatin on serum calcium levels was explored.

Methods: A cross-sectional observational study was conducted among 150 postmenopausal women with clinically diagnosed OA. Demographic and clinical data were collected, and serum levels of vitamin D, PTH, and calcium were assessed. Correlation analyses were performed to explore the associations between these biomarkers and OA severity. Multiple linear regression analysis was employed to assess the effect of simvastatin on serum calcium levels while controlling for confounding factors.

Results: The study revealed a significant negative correlation between serum vitamin D levels and OA severity (r = -0.31, p < 0.001), suggesting that lower vitamin D levels were associated with more severe OA symptoms. Conversely, serum PTH levels showed a positive correlation with OA severity (r = 0.27, p = 0.002), indicating that higher PTH levels were associated with increased OA severity. Simvastatin use did not significantly impact serum calcium levels (β = -0.04, p = 0.732).

Conclusion: This study emphasizes the significance of vitamin D and PTH in OA progression among postmenopausal women and underscores the need for proactive management of vitamin D status. Additionally, calcium and PTH regulation may play a pivotal role in OA pathogenesis. While further research is required to validate these associations and explore targeted interventions, these findings advocate for a holistic approach that integrates metabolic factors with established OA treatments to enhance patient outcomes and quality of life.


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Fatima tu zara H, Majeed Ullah, Atta A, Abdullah A. Relationship between Vitamin D and Parathyroid Hormone levels along with Simvastatin effect on serum calcium levels in postmenopausal women with osteoarthritis: Vitamin D, Parathyroid Hormone, and Simvastatin in Postmenopausal Women with Osteoarthritis. IRABCS [Internet]. 2023 Dec. 31 [cited 2024 Jun. 16];1(2):81-5. Available from:

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